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pentobarbital will lessen the level or outcome of gefitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will reduce the extent or effect of siponimod by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of siponimod using a drug that triggers average CYP2C9 in addition a

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